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A multicenter evaluation on the additive effect of nipradilol ophthalmic solution Takanori Nakagawa 1 , Tetsuzo Takahashi 1 , Tanaka Saie 2 , Hiromi Araki 3 , Ayumi Takei 4 , Akari Yui 5 , Nobuhiko Tachibana 5 , Tairou Kimura 5,6 , Atsushi Kanai 5 1Dept of Ophthalmol, Koshigaya Municipal Hosp 2Dept of Ophthalmol, Higashimatsudo Hosp 3Dept of Ophthalmol, Risshokouseikai Hosp 4Dept of Ophthalmol, Kiyosenomori General Hosp 5Dept of Ophthalmol, Juntendo Univ Sch of Med 6Ueno Eye Clinic pp.355-360
Published Date 2002/3/15
DOI https://doi.org/10.11477/mf.1410907644
  • Abstract
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We prospectively evaluated the additive or replacement effect of nipradilol ophthalmic solution on 88 eyes of 52 patients. Six institutions participated in the program. The cases comprised open-angle glau-coma 50 eyes, normal-tension glaucoma 19 eyes and ocular hypertension 19 eyes. All the cases had been treated by beta-blocker, carbonic anhybrase inhibitor, or prostaglandins with insufficient hypotensive effect. The intraocular pressure (IOP) averaged 18.1±0.2mmHg (mean±SD) initially and 16.8±0.3mmHg 2 or 3 months after initiation of nipradilol. The difference was significant (p<0.001) . The hypotensive effect was most pronounced when beta-blocker was replaced by nipradilol, with the IOP averaging 18.4±0.4mmHg initially and 16.8±0.3mmHg after nipradilol (p<0.001) .There were no significant changes in pulse rate, blood pressure or quantity of lacrimal fluid throughout.


Copyright © 2002, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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