Corneal endothelial cell changes twenty years after penetrating keratoplasty Kenji Inoue 1 , Chikako Kimura 1 , Shiro Amano 1 , Tetsuro Oshika 2 , Tadahiko Tsuru 3 1Dept of Ophthalmol, Univ of Tokyo Sch of Med 2Section of Corneal Transplantation, Univ Hosp, Univ of Tokyo Sch of Med 3Dept of Ophthalmol, Jichi Med Sch pp.685-689
Published Date 2001/4/15
DOI https://doi.org/10.11477/mf.1410907290
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We evaluated 15 eyes which showed clear cornea for 20 years or longer after penetrating keratoplasty. The causative lesion was keratoconus 10 eyes and herpetic keratitis 5 eyes. At the time of surgery, the patients were aged from 6 to 45 years, average 25.3±10.4 years. Preserved cornea within 3 days was used throughout. The endothelial cell population per mm2 averaged 998±343 10 years after surgery and 852±245 20 years after surgery. The rate of endothelial cell density loss thus averaged 12.1±16.3% between the last 10 years. This rate was independent of postoperative graft rejection, final visual acuity, causative corneal lesion, age of patient, nor age of the donor. The findings show that the corneal endothelial cells become stabilized after 10 years of surgery when the graft remains transparent after 20 years of surgery.

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