抗リン脂質抗体症候群による多発性・再発性・両眼性の網膜静脈閉塞症の3例

Multiple recurrent binocular retinal vein occlusion in three cases of antiphospholipid antibody syndrome

（17-D501-3）　抗リン脂質抗体症候群による網膜静脈閉塞症と考えられた3例を報告した。1例は両眼性・多発性の網膜静脈分枝閉塞症で，流産の既往と頭部MR1検査にて多発性の脳梗塞を認めた。他の2例は網膜動脈分枝閉塞症を伴った再発性の網膜中心静脈閉塞症と両眼性の網膜中心静脈閉塞症であった。全例に高血圧の既往はなく，凝固系は正常範囲内で，その他の血液検査に異常はなかったが，血中抗力ルジオリピン抗体は高値であった。網膜静脈閉塞症が多発性・再発性・両眼性にみられる場合，抗リン脂質抗体症候群を疑うべきであると考えられた。

We observed retinal vein occlusion in three females with antiphospholipid antibody syndrome. They were aged 68, 69 and 74 years respectively. The first case showed bilateral and multiple branch retinal vein occlusion. She had a history of spontaneous abortion. Magnetic resonance imaging showed multiple cerebral infarction. The second case had recurrent central retinal vein occlusion associated with branch retinal artery occlusion. Systemic hypertension was ruled out in all the cases. The parameters of the hematological and coagulation system were within normal range. Elevated anticardiolipin antibody in the blood was present as common features. These cases illustrate that antiphospholipid antibody syndrome may underly in retinal vein occlusions of unknown origin.