Subretinal penetration of peroral sparfloxacin Naoki Kimura 1 , Shin Sasao 1 , Mamoru Uenishi 1 , Akio Yamanaka 1 , Yoshihiko Nakamura 2 , Atsushi Azumi 3 1Dept of Ophthalmol, Kobe Kaisei Hosp 2Dept of Ophthalmol, Wadayama Hosp 3Dept of Ophthalmol, Kobe Univ Sch of Med pp.584-586
Published Date 1998/4/15
DOI https://doi.org/10.11477/mf.1410905811
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We measured the penetration of sparfloxacin into the subretinal fluid in 20 cases of rhegmatogenous retinal detachment. The patients received 100 mg of sparfloxacin on consecutive two days before and 4 hours on the day of surgery. Liquid high pressure chromatography showed the medium concentrations of sparfloxacin in the serum and subretinal fluid during surgery to be 0.41 and 0.71 Rg/ml respectively, showing the penetration ratio of 67%.

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