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Indocyanine green angiographic findings and pathophysiology of multifocal posterior pigment epitheliopathy Masanobu Uyama 1 , Hiroshi Matsunaga 1 , Takashi Matsubara 1 , Ichiro Fukushima 1 , Kenshirou Iwashita 1 , Takashi Kimoto 1 , Haruhiko Yamada 1 , Yoshimi Nagai 1 , Takuya Kitamura 1 1Department of Ophthalmology, Kansai Medical University pp.569-574
Published Date 1997/4/15
DOI https://doi.org/10.11477/mf.1410905310
  • Abstract
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Indocyanine green (ICG) fluorescence angiography was performed in 43 eyes of 25 cases of multifocal posterior pigment epitheliopathy (MPPE) . This clinical entity is characterized by numerous exudative patches in the posterior retina associated with serous retinal detachment. It was defined as an atypical form of central serous choroidopathy and was named as bullous retinal detachment by Gass (1973) . ICG angiography showed hyperfluorescence from the choroid due presumably to extravasation from the choriocapillaris. This feature became evident during the middle phase of angiography at about 1 minute after injection. Late phase angiogram 15 to 20 minutes after injection showed diffuse background hyperfluorescence in the choroid. These findings show that hyperpermeability of the choroidal vessels is the primary causative lesion, followed by intrastromal accumulation of extravasated choroidal fluid and by secondary impairment of the retinal pigment epithelium. We consider that this disease and central serous choroidopathy lie at both ends of a common morbid spectrum.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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