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Manifestations and treatment of ocular graft-versus-host disease in allogenic bone marrow transplantation Shoko Tanabe 1 , Junzo Hirano 1 , Mariko Murakami 1 1Dept of Ophthalmol, Japanese Red Cross Nagoya First Hosp pp.1749-1752
Published Date 1992/12/15
DOI https://doi.org/10.11477/mf.1410901421
  • Abstract
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We observed ocular complications as chronic graft-versus-host disease (GVHD) in 50% of 80 patients following allogenic bone marrow trans-plantation. The ocular manifestations were : itch-ing and photophobia with scant pathologic findings, diffuse superficial keratitis and/or keratitis filamentosa, corneal erosion, and corneal ulcer withoccasional perforation. Eleven patients necessitat-ed intensive treatment for longer periods. The treatment regimen comprised the following. Topi-cal tear substitute, antibiotics, corticosteroids, vita-min A oil and fibronectin from autoserum. Occlu-sion of the lacrimal punta. Injection of corticoste-roid in or around the lacrimal glands. Use of cor-neal flap in case of corneal perforation. Occlusion of the lacrimal punta was the most effective.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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