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Ocular symptoms and treatments of graft-versus-host disease Shoko Tanabe 1 , Yasuo Tabuchi 1 , Yukihiro Watanabe 1 , Junzo Hirano 1 , Mariko Murakami 1 1Dept of Ophthalmol, The Japanese Red Cross Nagoya First Hosp pp.113-116
Published Date 1989/2/15
DOI https://doi.org/10.11477/mf.1410210600
  • Abstract
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We report 6 cases with ocular complications of graft-versus-host disease following allogenic bone marrow transplantation. Hypolacrimation was the cardinal feature in the series. Superficial puntate keratopathy was the initial occurrence, which developed later into larger corneal erosion or ulcer.

We treated the cases with following measures. 1. Topical tear-substitute, antibiotics, corticostero-ids, vitamin A oil and fibronectin obtained from autoserum. 2. Occlusion of the lacrimal canaliculi with gelatin rod. 3. Injection of corticosteroids into or around the lacrimal gland. 4. Use of conjunctival flap in case of corneal perforation. 5. Continued wear of swimming goggles to diminish evaporation of tear fluid from the ocular surface.

One patient in the series lost vision due to exten-sive corneal ulcer with eventual perforation. Other cases followed favorable courses with the above measures, of which gelatin rod method seemed to be most effective. Although this procedure had to be repeated every few weeks because of recanaliza-tion of the canaliculi, it was our preferred method of treatment as it caused least damage to the tissue.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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