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Incidence of retinoblastoma in Shimabara district in Nagasaki Prefecture compared with the nationwide one Junnosuke Takano 1 , Naoki Imamura 1 , Masaki Sakuma 1 , Kazuto Akiyama 1 , Tsugio Amemiya 1 1Dept of Ophthalmol Nagasaki Univ Sch of Med pp.1343-1345
Published Date 1991/8/15
DOI https://doi.org/10.11477/mf.1410900774
  • Abstract
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A total of 34 patients with retinoblastoma was detected in Nagasaki Prefecture during a 22-year-period ending 1986.

Retinobastoma was unilateral in 23 and bilateral in 11.

Its incidence was 1/16,035 births for unilateral cases and 1/49,564 for bilateral ones. In Shimabara Disctrict in Nagasaki Prefecture, the overall inci-dence was peculiarly high at 1/10,330 births. Histor-ically, almost all the native inhabitants in Shimabara District were killed during a religious war in 1637, so that the current inhabitants are descendants of immigrants from Hyogo, Aichi and Shizuoka Prefectures in central Japan. We could ascertain the incidence of retinoblastoma in Tamba and Tajima districts in Hyogo Prefecuture to be 1/ 10,570 and 1/10,410 respectively.

The close similarity in the incidence of retinob-lastoma in these three districts appeared to be due to common genetic features.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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