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Bilateral retinoblastoma with a pineal tumor Yoshitaka Ohnishi 1 , Hiroshi Kumano 1 , Kazutaka Kimura 1 , Ken-ichi Kurakazu 2 1Dept of Oohthalmol, Fac of Med, Kyusyu Univ 2Kurakazu Eye Hosp, Tagawa pp.1925-1928
Published Date 1989/12/15
DOI https://doi.org/10.11477/mf.1410211070
  • Abstract
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A 21-month-old male infant presented with leu-kokoria in the left eye. His family history was inconspicuous. The enucleated eye was diagnosed, histologically, as well-differentiated retinoblas-toma. The optic nerve was not invaded by tumor cells. There were two discrete lesions in the right eye. They were effectively treated with photodynamic therapy using a hematoporphyrin derivative and argon laser without radiotherapy. Three months later, recurrent vomiting started. Pleocytosis was found in the cerebrospinal fluid. Computed tomography showed a tumor in the pineal gland.Intense radiation and chemotherapy led to the disappearance of the tumor. The child died from renal failure at 36 months of age. No post mortem examination was performed. Although the histological proof of pineal tumor is lacking, we diagnosed the case, clinically, as trilateral retinob-lastoma. Computed tomography was instrumental in the diagnosis and facilitated the designing of therapeutic approach.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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