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Japanese

Influence of drugs on the human trabecular meshwork--1. Vitamin A Takuo Hoya 1 , Yoshio Urakawa 1 , Morito Miyazaki 1 , Atsushi Ishihara 1 , Jiro Amaya 1 , Fujio Amari 1 , Katsuzo Segawa 1 1Dept of Ophthalmol, Sch of Med, Shinshu Univ pp.539-543
Published Date 1989/4/15
DOI https://doi.org/10.11477/mf.1410210717
  • Abstract
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We cultured the trabecular meshwork for 2 weeks using solid agar method. The tissue was obtained from 4 eyes postmortem aged 65, 67, 84 and 87 years each. The cultured specimens were divided into 3 groups: 1) control group, 2) chon-droitin-6-sulfate (CD6S) added group, 3) CD6S + Vitamin A acetate (VA) added group.

The samples were then prepared for transmission electron microscopy. We measured the percentage of areas of cellular space, extracellular material space and empty space in the endothelial meshworkusing computer-assisted morphometry.

When examined 2 weeks after addition of CD6S, all the specimens showed significant increases in extracellular material followed by decrease of empty space in the endothelial meshwork. A signi-ficant decrease of extracellular material and an increase in empty space occurred one day after addition of VA.

A similar decrease of extracellular material was seen in cultured specimen obtained by trabeculectomy after addition of VA.

The finding seemed to suggest that Vitamin A may directly influence the trabecular meshwork cells with a potential of clinical application.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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