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Risk factors for age-related macular degeneration with choroidal neovascularization Fumio Shiraga 1 , Nobuhiko Matsuo 1 , Toshihiko Tsuji 1 , Masayoshi Mihara 1 , Kouji Nasu 1 1Dept of Ophthalmol, Okayama Univ Med Sch pp.544-548
Published Date 1989/4/15
DOI https://doi.org/10.11477/mf.1410210718
  • Abstract
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We evaluated the association between age-related macular degeneration (ARMD) with chor-oidal neovascularization and risk factors for ather-osclerosis.

A sample of 82 patients with hemorrhagic, exudative or disciform lesions was collected. The frequency of cigarette smokers differed significant-ly between our sample and general population. The estimated odds ratio was 2.31 (p<0.02). A dose-response relationship could be demonstratedbetween cigarette smoking and activity of neovas-cular membrane. In males in the 8th decade, total cholesterol levels and LDL-cholesterol levels of our sample increased significantly. In males in the 7th decade, HDL-cholesterol levels decreased signifi-cantly, compared with general population. No sig-nificant association was demonstrated between this disease and systemic hypertension.

The results suggested that cigarette smoking might stimulate the development of choroidal new vessels and inhibit the involution of neovascular membrane.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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