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Keratoderma pigmentosum and aging of corneal endothelium with impaired DNA repair Mitsutoshi Nakamura 1 , Koji Nomura 1 , Junko Kawakami 1 , Kiyoshi Okubo 1 , Masamitsu Ichihashi 2 1Dept of Ophthalmol, Sch of Med, Kobe Univ. 2Dept of Dermatol, Sch of Med, Kobe Univ. pp.1041-1044
Published Date 1988/9/15
DOI https://doi.org/10.11477/mf.1410210505
  • Abstract
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Xeroderma pigmentosum is an autosomal reces-sive hereditary disease, characterized by hypersen-sitivity to ultraviolet light and by disturbance of DNA repair after exposure to ultraviolet light. We evaluated the corneal endothelium in 8 patients with keratoderma pigmentosum by means of specular microscope. In 7 patients, we observed decreased cell density and hexagonality and in-creased coefficient of variation in cell areas when compared with normal persons. The corneal en-dothelial age ratio (EAR) correlated well with clonogenic ultraviolet survival mean lethal dose and with unscheduled DNA synthesis (UDS).

As the corneal endothelium has no mitotic activ-ity, the aging of corneal endothelium manifests decrease of cell density and increase of cell varia-bility (CV). Above findings led us to presume that a close relationship would exist between aging of corneal endothelium and activity of DNA repair.

Rinsho Ganka (Jpn J Clin Ophthalmol) 42(9) : 1041-1044, 1988


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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