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老人性円盤状黄斑変性症から硝子体出血を起した2症例3眼について述べた. この中,第1例右眼は黄斑部のmottlingから,浮腫,漿液性ついで出血性網膜色素上皮剥離,硝子体出血,円盤状黄斑変性とGassの述べた進行様式を示した.第2例左眼も,途中からであるが,第1例に準じた進展を示した.
第1例は両眼にウロキナーゼの硝子体内注入を行い,さらに右眼は水晶体摘出と前部硝子体切除を行ったが,結局は失明に終った.第2例はウロキナーゼの点滴静注が行われた.結果的には,観血的治療より,非観血的治療が好ましいことになるが,こうした出血を起す段階で,出血を防止する手段を講じることの必要性を痛感する.
我々の外来で見られ,3ケ月以上follow upできた老人性円盤状黄斑変性症は,14例20眼で,硝子体出血を見たものは2例3眼である.
Massive vitreous hemorrhage occurred secondary to senile disciform macular degeneration in 3 eyes in 2 patients.
In the first case, a 72-year-old male, vitreous hemorrhage developed from the mottled area in the macula in the right eye during the course of obser-vation. In the fellow eye, massive vitreous hemor-rhage occurred consequent to hemorrhagic detach-ment of retinal pigment epithelium.
In the second case, a 71-year-old male, vitreous hemorrhage occurred secondary to apparent serous detachment of the retinal pigment epithelium asso-ciated with subretinal neovascularization. Numerous macular drusen were present in the fellow eye.
Systemic or intravitreal urokinase did not appear to favorably influence the clinical course.
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