Carbonic Anhydrase Inhibitorsの眼圧及び血清電解質へ及ぼす影響について

Clinical and Experimental Studies on Carbonic Anhydrase Inhibitors

I．緒言

　我々は人の正常眼，緑内障眼及び家兎の正常眼並びに実験的高眼圧眼についてAcetazolamide（Diamox），Dichlorphenamide （Daranide），及びMethazolamide （Neptazane）の3種のCarbonic Anhydrase Inhibitorsの眼圧に及ぼす影響と前2者を連続投与した時の血清電解質へ及ぼす影響について検討したのでその成果を報告する。

The effects of Carbonic Anhydrase Inhibi-tors upon the intraocular pressure of human beings and rabbits were studied, and the results were obtained as follows;

1) The hypotensive effect of Acetazolamide was the most prominent. The effect of Dich-lorphenamide was almost equal to that of Methazolamide and these exhibited slower but more prolonged hypotensive action than Acet-azolamide.

2) The prolonged administrations of Acetazo-lamide or Dichlorphenamide caused a remar-kable decrease of serum potassium.