Hydroxy-phenylbutazone （Tanderil）の抗炎症作用に関する実験的研究

Effect of Hydroxy-phenylbutazone (Tan-deril) on experimentally induced ocular inflammation.

I．緒言

　著者等は先の第27回中部眼科学会に於て，タンデリールの臨床使用経験について発表^1）したが，その後，水川・湖崎^2），笛田・新保・岩田^3），植村・平山^4）等も相次いで使用成績を報告し，何れもそのすぐれた消炎作用を認めている。著者等はタンデリールの臨床使用に先立つて，その炎症抑制作用並に消炎作用を検討すべく動物実験を行つたが，この程漸く病理組織学的検査を終つたので，その実験成績について報告する。

In rabbit eyes, iridocyclitis was produced by glycerin-injection into anterior chamber. Six were treated with 100mg per kg of Tanderil by intramuscular injection every 8 hours, star-ting 4 hours before the glycerin-injection and six control rabbits did not receive any treat-ment.

At 24 and 48 hours after the glycerin-injec-tion, the inflammatory reactions were clini-cally observed and anti-inflammatory effect of Tanderil was examined. At 72 hours theeyes were removed and were histologically examined.

The results obtained were as follows: