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Abducens palsy in a case of drug-induced multiple cranial palsies Kumiko Yoshimoto 1 , Takeya Kono 1 , Manabu Yamamoto 1 , Kunihiko Shiraki 1 1Dept of Ophthalmol and Vis Sci, Osaka City Univ Grad Sch of Med pp.965-969
Published Date 2013/6/15
DOI https://doi.org/10.11477/mf.1410104777
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Abstract. Purpose:To report a case with abducens palsy as the initial manifestation of multiple cranial nerve palsies following systemic treatment with tumor necrosis factor-α Case:A 41-year-old male presented with diplopia since 3 weeks before. He had been receiving peroral adalimumab, a TNF-α preparation, for Crohn disease. Findings:Routine ophthalmological findings were within normal limits except restricted abduction of the right eye. He was diagnosed with right abducens palsy. He developed difficulty in closure of the right eye 18 days later, followed by right trigeminal palsy and facial palsy 25 days later. After discontinuation of adalimumab, abducens palsy cured 3 months later. Cranial nerve palsies subsided one year later. Conclusion:This case illustrates that abducens palsy may manifest prior to multiple cranial palsies. There is a possibility that systemic adalimumab may have induced cranial nerve palsies.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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