多施設における緑内障患者の実態調査2012年度版―正常眼圧緑内障と原発開放隅角緑内障

Multi-institutional survey on normal-tension and primary open-angle glaucoma in 2012

要約　目的：正常眼圧緑内障（NTG）と原発開放隅角緑内障（POAG）患者の使用薬剤を調査する。対象と方法：2012年3月12～18日に受診したNTGとPOAG患者の使用薬剤を2007年，2009年の調査と比較した。結果：薬剤数はPOAG（1.7±1.0剤）がNTG（1.3±0.7剤）より多かった。単剤例は両病型ともラタノプロスト，トラボプロストの順で多かった。2剤例は両病型でプロスタグランジン関連薬＋β遮断薬が最多であったが，調査ごとに減少していた。配合薬は単剤例でNTG 6.5％，POAG 15.1％，2剤例でNTG 17.8％，POAG 32.6％であった。結論：ラタノプロストが最多で，配合薬が使用されつつある。NTGとPOAGでは使用薬剤に差がみられた。

Abstract.　Purpose：To report the current status of eyedrops for glaucoma. Cases and Method：This survey was made on the modality of topical treatment for normal-tension glaucoma（NTG）and primary open-angle glaucoma（POAG）during one week in March 2012 in 42 institutions. Report was obtained on 3,569 patients comprising 1,503 males and 2,066 females. The age ranged from 9 to 100 years, average 67 years. Findings were compared with similar studies made in 2007 and 2009. Results：POAG patients were receiving an average of 1.7±1.0 eyedrops. NTG patients were receiving 1.3±0.7 eyedrops. The difference was significant（p＜0.0001）. Among medications used as monotherapy for NTG, latanoprost was the most frequent（30.7％）, followed by travoprost（12.2％）and tafluprost（8.9％）. For POAG, latanoprost was most frequently used（35.3％）, followed by travoprost（10.3％）and latanoprost-timolol（10.1％）. When two medications were used, prostaglandin combined with beta-blockers was the most frequent. Eyedrops in fixed combination were used for 6.5％ of NTG and 15.1％ of POAG patients as monotherapy and for 17.8％ of NTG and 32.6％ of POAG two medications were used. Conclusion：Latanoprost was the most frequently used as a whole either as monotherapy or combination of multiple medications. There were differences in medication between NTG and POAG.