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Harada disease in a case during interferon therapy for chronic hepatitis C Chiaki Sugiyama 1 , Tadashi Nakauchi 1 , Masaaki Hayakawa 1 , Nana Sasaki 1 , Yasuyuki Nagao 2 , Mika Okita 2 , Hirokazu Oyamada 2 , Toyokazu Okami 1 1Dept of Ophthalmol,Matsushita Memorial Hosp 2Dept of Gastroenterol,Matsushita Memorial Hosp pp.741-746
Published Date 2012/5/15
DOI https://doi.org/10.11477/mf.1410104216
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Abstract. Purpose:To report a case who developed Harada disease during peroral interferon therapy for chronic hepatitis C. Case:A 66-year-old female presented with impaired visual acuity and metamorphopsia in her right eye since 2 weeks before. She had been diagnosed with chronic hepatitis C one year before. She had been receiving peroral interferon since 10 weeks before. Findings:Corrected visual acuity was 0.05 right and 0.5 left. Both eyes showed signs of iritis and exudative retinal detachment in the posterior fundus. Fluorescein angiography showed multiple dye leakage and pooling of fluorescein in the subretinal space. These findings led to the diagnosis of Harada disease. Discontinuation of interferon with pulsed corticosteroid therapy was followed by disappearance of retinal detachment. Sunset-glow fundus appeared in both eyes 10 months later. Conclusion:This case illustrates that systemic interferon therapy may induce Harada disease as an unusual complication.


Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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