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A case of severe aplastic anemia following long-term treatment with systemic acetazolamide Kazuaki Nishino 1 , Fujiko Yoshida 1 , Akari Nitta 1 , Mieko Saito 1 , Kazuuchi Saito 1 1Kaimeidoh Ophthalmic and Dental Clin pp.563-567
Published Date 2011/4/15
DOI https://doi.org/10.11477/mf.1410103629
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Abstract. Purpose:To report a case of severe aplastic anemia after long-term systemic treatment with acetazolamide for spinocerebellar ataxia. Case:A 71-year-old female presented with myodesopsia since 2 hours before. She had been diagnosed with spinocerebellar ataxia type 6 15 years before. She had been receiving peroral acetazolamide for 10 years. She underwent cataract surgery 9 years before resulting in visual acuity of 0.9 right and 1.0 left. Findings:Her corrected visual acuity was 0.4 right and 0.5 left. Both eyes showed nystagmus,hemorrhage and soft exudates around the optic disc. Systemic studies showed pancytopenia. Bone marrow findings led to the diagnosis of severe aplastic anemia. Retinal hemorrhage exacerbated 8 months later resulting in visual acuity of 0.05 right and 0.02 left. She passed away due to pneumonia 11 months after her initial visit. Conclusion:The present case is characterized by myodesopsia as the initial manifestation of severe aplastic anemia. Long-term peroral acetazolamide may have been involved as a causative factor of aplastic anemia.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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