血清IgE値とLASIK合併症との関連

Relationship between serum IgE levels and complications after LASIK

要約　目的：血清のIgE値とLASIK術後合併症との関連の報告。対象と方法：過去6年間にLASIKを行った症例のうち，250例250眼を対象とした。血清IgE値が170IU/ml以上の96眼とこれ未満の154眼の2群についてのLASIK合併症の頻度を検索した。合併症は，びまん性層間角膜炎，角膜フラップのストリエ，角膜上皮迷入の3種に分けた。結果：びまん性層間角膜炎は250眼中7眼（2.8％）に生じ，IgE高値群では6眼（6.3％），低値群では1眼（0.7％）であり，有意差があった（p＝0.0139）。ストリエは250眼中6眼（2.4％）に生じ，IgE高値群では4眼（4.2％），低値群では2眼（1.3％）であり，有意差はなかった（p＝0.208）。角膜上皮迷入はなかった。結論：血清IgE値は，LASIK後のびまん性層間角膜炎の発症に関連がある可能性と，LASIK後の合併症の予測に有用である可能性がある。

Abstract.　Purpose：To report the relation between serum IgE level and incidence of complications after LASIK. Cases and Method：This retrospective study was made on 250 eyes of 250 cases who were randomly selected from patients who received LASIK during the past 6 years. The right eyes were evaluated throughout. The 250 cases were divided into two groups：96 cases who had 170IU/ml or more as serum IgE, and 154 cases who had IgE below this level. Results：Diffuse lamellar keratitis developed in 7 out of 250 eyes（2.8％）. It occurred in 6 eyes（6.3％）in cases with higher IgE level and in one eye（0.7％）in those with lower IgE level. The difference was significant（p＝0.0139）. Corneal striae developed in 6 out of 250 eyes（2.4％）. There was no significant difference in the incidence between the two groups. No eye developed epithelial ingrowth in the whole series. Conclusion：There is a possibility that serum IgE level is related with the incidence of complications after LASIK and that serum IgE level may serve as a prognostic factor for post-LASIK complications.