A four-year review of intraocular malignant lymphoma Tamaki Sumi 1 , Atsuki Fukushima 1 , Nobutsugu Hayashi 2 , Yuji Koura 1 , Takeki Komatsu 1 , Masatsugu Hashida 3 , Norio Masaoka 4 , Hisayuki Ueno 1 1Dept of Ophthalmol,Kochi Med Sch 2Dept of Ophthalmol,Okabayashi Hosp 3Dept of Ophthalmol,Machida Hosp 4Masaoka Eye Clinic pp.809-813
Published Date 2003/5/15
DOI https://doi.org/10.11477/mf.1410101246
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Abstract. We observed intraocular malignant lymphoma in 9 eyes of 5 patients during the past 4 years. The series comprised one male and four females. Their ages ranged from 59 to 81 years,average 70 years. The presenting symptoms were impaired vision 3 cases,blurring 1 case,and seeing flies 1 case. Extraocular malignant lymphoma was ruled out in all the cases after their initial visit. Persistent vitreous opacity was present as a common feature in the 5 cases. Intraocular malignant lymphoma was diagnosed by vitreous biopsy. The ratio of interleukin(IL)-10 to IL-6 was elevated in 4 examined cases. This ratio had no relevance to later clinical course. Four cases received whole eye irradiation,three of which received additional chemotherapy. Intracranial involvement developed in 4 cases 4 to 48 months,average 23 months,after onset of eye symptoms. These 4 cases resulted in fatal outcome.

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