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要約 目的:生後1か月以内に遺伝性網膜芽細胞腫が発見され,両眼に多発化した2症例の報告。症例:生後5日の女児には片眼の1か所,生後1か月の男児には両眼の5か所に網膜芽細胞腫が発見された。両者とも父親が網膜芽細胞腫であった。すぐに光凝固を行い,腫瘍が瘢痕化したが,両症例とも腫瘍が両眼に多発した。光凝固と冷凍凝固を繰り返したが,腫瘍が多発する傾向が続き,化学療法を行った。両症例とも生後1年以降は腫瘍の発生または再発はない。結論:遺伝性網膜芽細胞腫が早期に発症した症例では,腫瘍の発生と再発に十分な注意が必要である。
Abstract. Purpose:To report two cases of hereditary retinoblastoma that rapidly multiplied after detection soon after birth. Cases:Retinoblastoma was detected in a female infant 5 days after birth and a male infant one month after birth. Only one eye was affected in both cases. The tumor was present as a single focus in the former and as 5 foci in the latter. Their fathers had been patients of retinoblastoma. The tumors became scarred after photocoagulation. Soon later, retinoblastoma developed bilaterally and grew rapidly in both cases in spite of photocoagulation and cryotherapy. Systemic chemotherapy was effective in preventing further occurrence of retinoblastoma in both cases after one year of age. Conclusion:Early-onset hereditary retinoblastoma need utmost care regarding occurrence and recurrence of tumors.
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