Japanese

Efficacy and comfort of 0.1% olopatadine hydrochloride ophthalmic solution for allergic conjunctivitis in the Japanese.: Comparison with 0.025% levocabastine hydrochloride ophthalmic solution Shigeaki Ohno 1 , Eiichi Uchio 2 , Etsuko Takamura 3 , Teruo Nishida 4 , Robert L. Jones 5 , Fred K. Kurata 6 , Mark B. Abelson 7 1Dept of Ophthalmol and Vis Sci,Hokkaido Univ Grad Sch of Med 2Dept of Ophthalmol,Fukuoka Univ,Fac of Med 3Dept of Ophthalmol,Tokyo Women's Med Univ 4Dept of Ophthalmol,Yamaguchi Univ Grad Sch of Med 5Newport Eye Cent 6East West Eye Inst 7Schepens Eye Res Inst and Harvard Med Sch pp.251-255
Published Date 2007/2/15
DOI https://doi.org/10.11477/mf.1410101555
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Abstract. Purpose:To compare the efficacy and comfort of 0.1% olopatadine hydrochloride and 0.025% levocabastine hydrochloride ophthalmic solution for allergic conjunctivitis in the Japanese. Cases and Method:This prospective clinical study was made on 20 Japanese and Japanese Americans. All had a history of allergic conjunctivitis. The series comprised 14 males and 6 females. Their age ranged from 19 to 61 years,average 38 years. One drop of 0.1% olopatadine hydrochloride was instilled in one eye. The fellow eye received one drop of 0.025% levocabastine hydrochloride ophthalmic solution. Both eyes received one drop each of allergen 210 minutes later. Comfort and effect were numerically evaluated by test persons. Results:Olopatadine induced greater reduction in itching and better comfort than levocabastine(p<0.05 each). Olopatadine induced no burning or stinging sensation throughout. Levocabastine induced stinging in 25% and burning in 20% of test persons. Olopatadine was preferred to levocabastine by 75% of test persons. Conclusion:Olopatadine was more effective than levocabastine in comfort and reducing itching.


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