Two cases of intraocular malignant lymphoma Yuri Kobayashi 1 , Yoko Kato 1 , Tadayuki Nishide 1 , Yasuhito Iijima 1 , Hisashi Ohshiro 2 , Yoshiaki Inayama 2 , Hiroshi Goto 3 , Nobuhisa Mizuki 1 1Dept of Ophthalmol,Yokohama City Univ Sch of Med 2Dept of Pathol,Yokohama City Univ Hosp 3Dept of Ophthalmol,Tokyo Med Univ pp.221-227
Published Date 2007/2/15
DOI https://doi.org/10.11477/mf.1410101550
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Abstract. Purpose:To report two cases of intraocular malignant lymphoma. Cases:Both were females aged 73 and 69 years respectively. Impaired visual acuity in both eyes was the chief complaint in both cases. Corrected visual acuity was 0.2 and light perception in one case and 0.01 and 0.4 in the other. All the affected 4 eyes showed signs of iritis and vitreous opacity. Funduscopy was possible in one eye only and showed diffuse chorioretinal atrophy. One case was diagnosed with malignant lymphoma by the presence of class V atypical lymphocytes by vitreous biopsy. In the other case,vitreous biopsy gave ambiguous results after topical corticosteroid proved futile. Intravitreal levels of cytokines showed a high possibility of malignant lymphoma by increased IL-10 and IL-10/IL-6 ratio. All the affected eyes received radiation therapy. Results:There has been no recurrence or metastasis to the central nervous system after follow-up for 9 and 13 months respectively. Final visual acuity was 0.3/hand motion in one case,and 1.2/1.2 in the other. Conclusion:Instillation of corticosteroid may decrease the positive rate in cytological diagnosis of malignant lymphoma. Intravitreal IL-10 and IL-6 levels may be of value as adjuvant diagnostic tool.

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