硝子体生検時に眼内灌流を行った検体の有用性

Vitreous biopsy during vitrectomy with and without irrigation

要約　目的：原因不明のぶどう膜炎に行った硝子体生検の結果に，硝子体灌流の有無が及ぼす影響の報告。対象と方法：過去6か月間に硝子体生検を行ったぶどう膜炎12例16眼を対象とした。男性11眼，女性5眼で，平均年齢は69±11歳である。まず無灌流の状態で，続いて灌流下で採取した検体を検索した。結果：IL-6値は，10眼で無灌流，6眼で還流下のほうが高値であった。IL-10値は4眼で検出できた。1眼で無灌流，3眼で還流下のほうが高値であった。IL-10/IL-6が算出できた4眼では，全例が1.0以上であった。病理細胞診の結果は，無灌流時と灌流時とで差がなかった。結論：ぶどう膜炎に対する硝子体生検の結果に，硝子体灌流の有無は影響しなかった。

Abstract.　Purpose：To report the outcome of vitreous biopsy for uveitis during vitrectomy with and without irrigation. Cases and Method：This study was made on 16 eyes of 12 cases who received vitreous biopsy during the past 6 months. The series comprised 11 male and 5 female eyes. The age averaged 69±11 years. Vitreous sample was obtained first without and later with irrigation. Findings：Level of IL-6 was higher in 10 eyes sampled without irrigation and was higher in 6 eyes with irrigation. Level of IL-10 could be evaluated in 4 eyes. It was higher in one sample obtained without and in 3 samples obtained with irrigation. Ratio of Il-10 and IL-6 was 1.0 or over in all the 4 eyes. There was no difference in the cytological diagnosis between samples obtained with and without irrigation. Conclusion：There was no difference in the outcome of vitreous biopsy obtained with and without irrigation.