ラタノプロスト点眼中の正常眼圧緑内障患者に対する塩酸ブナゾシン点眼液の眼循環と眼圧における併用効果の検討

Additive effect of bunazosin hydrochloride on intraocular pressure and disc circulation in patients of normal-tension glaucoma treated by latanoprost

目的：ラタノプロスト点眼中の正常眼圧緑内障眼に，塩酸ブナゾシン点眼を追加併用後の眼圧と眼循環の検索。対象と方法：ラタノプロスト点眼中の正常眼圧緑内障9名を対象とした。年齢は57～76歳，眼圧は10～18mmHg，平均13.2±2.3mmHgであった。1眼に塩酸ブナゾシン点眼を追加し，他眼にプラセボを点眼して対照とした。点眼前と点眼開始2週間後に，血圧，脈拍，眼圧を測定し，乳頭縁と乳頭近傍網膜の血流をハイデルベルク網膜血流計で計測した。結果：塩酸ブナゾシン追加点眼後に，乳頭縁と乳頭近傍網膜の血流が有意に増加した。対照眼では変化はなかった。眼圧は追加点眼群で有意に下降した。血圧，脈拍，眼灌流圧に有意な変化はなかった。結論：ラタノプロスト点眼中の正常眼圧緑内障眼への塩酸ブナゾシン点眼は，眼圧をさらに下降させ，乳頭とその周囲の循環を改善させる。

Purpose：To evaluate the additive effect of bunazosin hydrochloride on intraocular pressure and disc circulation in patients of normal-tension glaucoma treated by latanoprost.

Cases and Method：The study involved 9 patients of normal-tension glaucoma treated by latanoprost. The ages ranged from 57 to 76 years. The intraocular pressure（IOP）ranged from 10 to 18 mmHg,average 13.2±2.3 mmHg. Each patient received,additionally,bunazosin in one eye and placebo in the fellow eye. Measurements were made as to blood pressure,pulse rate and IOP before and 2 weeks after start of bunazosin. Blood flow in the optic disc and juxtapapillary retina was similarly measured using a Heidelberg Retina Flowmeter. Results：Blood flow in the optic disc and juxtapapillary retina showed significant increases in eyes receiving bunazosin and no changes in fellow eye. IOP decreased significantly in eyes receiving bunazosin. There were no changes in blood pressure,pulse rate,or perfusion pressure. Conclusion：Bunazosin reduces IOP and increases circulation in the optic disc and juxtapapillary retina when added to latanoprost in patients of normal-tension glaucoma.