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要約 目的:眼圧測定時間を限定し正常眼圧緑内障に対するラタノプロストの眼圧下降効果を検討。症例と方法:正常眼圧緑内障と診断した25例25眼を対象とした。男性12例,女性13例。年齢は37~87歳(平均62歳)。ラタノプロストを1日1回点眼させ,午前9~11時の間に圧平眼圧計で眼圧を測定した。眼圧下降が10%未満,または他剤に変更を必要とした症例をnon-responderと定義した。結果:基準眼圧は15.5±2.4mmHgであった。平均眼圧下降率は6か月後に18.0%,12か月後に20.7%であった。12か月の時点でnon-responderが4例(27%)あった。結論:眼圧測定時間を限定した検討で,正常眼圧緑内障に対するラタノプロスト単剤点眼は有意な眼圧下降効果を示した。長期的には他剤の追加を必要とする可能性が高い。
Abstract. Purpose:To report the hypotensive effect of latanoprost for normal-tension glaucoma. Cases and Method:This study was made on 25 eyes of 25 patients comprising 12 males and 13 females. Their ages ranged from 37 to 87 years,average 62 years. Intraocular pressure(IOP)was measured between 9 to 11 o'clock in the morning. The base line IOP averaged 15.5±2.4mmHg. Patient was defined as non-responder when IOP decreased by 10% or less or when latanoprost had to be switched to other medications. Results:The average IOP reduction rates 18.0% 6 months later and by 20.7% 12 months later. There were 4(27%)non-responders at 12 months. Conclusion:Latanoprost induced significant IOP decrease in normal-tension glaucoma when IOP was measured at about 10 o'clock in the morning. There is a possibility to have to replace latanoprost by other medications on a long-term basis.
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