低眼圧緑内障に対する塩酸ブナゾシン点眼の効果．—眼脈流量を中心に

Effect of topical bunazosin hydrochloride in low-tension glaucoma, especially on pulsatile ocular blood flow

　塩酸ブナゾシン（α₁遮断剤）点眼液が，低眼圧緑内障の眼脈流量や視野等に及ぼす影響について検討した。BFA （日本バイオラッド）によって解析された眼脈流量は，低眼圧緑内障で111.1±32.6μl／minと，正常者（186.1±43.2）や原発開放隅角緑内障（137.2±50.4）よりも有意に低値であった。眼脈流量は0.025％塩酸ブナゾシン点眼を開始すると徐々に増加し，3か月後には50.3％の増加率であった。眼圧は平均0.9mmHg下降した。3〜5か月後の視野検査では18眼中6眼に改善を認め，改善群では眼脈流量の増加率が非改善群より有意に高かった。今後，低眼圧緑内障の治療薬として応用の可能性がある。

The effects of topically applied bunazosin hydro-chloride, an alpha-1 blocker, were studied in regard to pulsatile ocular blood flow (POBF) and visual field in patients with low-tension glaucoma (LTG). POBF analyzed by BFA (Japan BIO-RAD) in LTG (111.1±32.6μl/min) was significantly lower than that in normal subjects (186.1±43.2) or patientswith primary open-angle glaucoma (137.2±50.4). POBF in LTG gradually increased by 0.025% bun-azosin hydrochloride (twice a day) with an increase rate of 50.3% in the 3rd month, The mean decrease of intraocular pressure was 0.9mmHg. 6 eyes out of 18 showed improvement in visual field in the 3rd to 5th month. The increase rate of POBF in these eyes was significantly higher than that in unimproved eyes. Bunazosin hydrochloride prom-ises to be as a therapeutic drug for LTG in the future.