抗sulfated glucuronyl lactosaminyl paragloboside抗体や抗カルジオリピン抗体が陽性で脊髄空洞形成を認めた急性横断性脊髄炎

Acute Transverse Myelitis Presenting with Syrinx Formation Associated with Anti-sulfated Glucuronyl Lactosaminyl Paragloboside Antibody and Anticardiolipin Antibody

　抗核抗体や免疫複合体が陽性で，さらにIgM抗sulfated glucuronyl lactosaminyl paragloboside（SGLPG）抗体や低力価のIgG抗カルジオリピン抗体（aCL）を認め，MRIで第7〜9胸髄レベルに空洞形成を認めたlupoid sclerosis類似の急性横断性脊髄炎（ATM）の1例を報告した。ATMで抗SGLPG抗体を認めた報告は本例が最初であり，本例の発症機序として抗SGLPG抗体やaCLなどにより血管内皮細胞の障害から脳血液関門の破綻をきたし，脊髄障害を生じた可能性が考えられた。

A 37-year-old woman was admitted because of rapidly progressive unsteady gait, back pain and ascending dysesthesia below the lower chest level. On admission, she showed ataxic gait, positive Romberg's sign, severely impaired deep sensation of lower extremities, and vesico-rectal disturbance. Deep tendon reflexes in both lower extremities were brisk, while normal in the upper extremities. Babinski's sign was positive on both sides.