An Autopsy Case of Amyotrophic Lateral Sclerosis with Concomitant Alzheimer's and Incidental Lewy Body Diseases Mu Su 1 , Koichi Wakabayashi 1 , Yoshinori Tanno 2,3 , Takashi Inuzuka 2 , Hitoshi Takahashi 1 1Departments of Pathology, Brain Research Institute, Niigata University 2Departments of Neurology, Brain Research Institute, Niigata University Keyword: amyotrophic lateral sclerosis , Alzheimer's disease , Parkinson's disease , Lewy body pp.931-936
Published Date 1996/10/1
DOI https://doi.org/10.11477/mf.1406901013
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We report a 72-year-old man with sporadic amyotrophic lateral sclerosis (ALS) who showed concomitant histopathology of Alzheimer's disease (AD) and incidental Lewy body disease. The patient presented at the age of 70 years with distal upper limb amyotrophy. Thereafter, gait distur-bance and respiratory distress progressed. Neuro-pathological examination showed mild frontal lobe and anterior spinal root atrophy. There was mode-rate loss of upper and lower motor neurons, and Bunina bodies and skein-like inclusions were pre-sent in the spinal anterior horns and facial and hypoglossal nuclei, confirming the pathology ofALS.

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