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An Autopsy Case of Dementia of Lewy Bodies Associated with Abundant Argyrophilic Grains Kenichi Oshima 1,3 , Kuniaki Tsuchiya 2,3 , Hiroshi Miyazaki 4 , Shuji Iritani 5 , Kazuhiro Niizato 1,3 , Ryosuke Nakamura 1,3 , Hideki Ueno 1,3 , Mizuho Tohgi 1,3 , Haruhiko Akiyama 3 , Heii Arai 6 1Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital 2Laboratory Medicine and Pathology, Tokyo Metropolitan Matsuzawa Hospital 3Department of Psychogeriatrics, Tokyo Institute of Psychiatry 4Department of Neurology, Yokosuka Kyosai Hospital 5Department of Psychiatry, Nagoya University School of Medicine 6Department of Psychiatry, Juntendo Medical University Keyword: Lewy body , argyrophilic grain , autopsy case pp.695-700
Published Date 2005/8/1
DOI https://doi.org/10.11477/mf.1406100067
  • Abstract
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We report an autopsy case showing neuropathologically abundant Lewy bodies and argyrophilic grains.

 A Japanese woman without hereditary burden developed parkinsonian gait at the age of 74, following by insomnia, memory disturbance, delirium, resting tremor, rigidity, and retropulsion. About 8 months later, a visual hallucination, concerning small worms, children, and so on,became obvious. About 16 months later, malignant lymphoma was detected. About 17 months later, she was died of pneumonia. The total duration of illness was approximately one year and five months.

 The weight of the brain was 1,153g before fixation. Depigmentation of the substantia nigra and locus ceruleus was prominent. Many argyrophilic grains were seen in the temporal lobe (T3, T4), amygdala, and hippocampal CA1. Some ballooned neurons were found in the amygdala. Many Lewy bodies were encountered in the transentorhinal region and cingulated gyrus. A few Lewy bodies were seen in the temporal, frontal, and parietal lobes. In this case, neuropathological examination is compatible for dementia of Lewy bodies and argyrophilic grain dementia, and clinical course is consistent with dementia of Lewy bodies. This report may contribute to the elucidation of the clinicopathological hallmarks of argyrophilic grain dementia and dementia with Lewy bodies.

(Received : October 19, 2004)


Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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