Japanese

Incidental Occurrence of Lewy Bodies in the Brains of Elderly Patients : The Relevance to Aging and Parkinson's Disease Koichi Wakabayashi 1 , Hitoshi Takahashi 1 , Kiyomitsu Oyanagi 2 , Fusahiro Ikuta 1 1Department of Pathology, Brain Research Institute, Niigata University 2The Center for Materials of Brain Diseases, Brain Research Institute, Niigata University Keyword: Parkinson's disease , Lewy body , substantia nigra , locus ceruleus , quantitative investigation pp.1033-1038
Published Date 1993/11/1
DOI https://doi.org/10.11477/mf.1406900556
  • Abstract
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The Lewy body (LB) is a cytoplasmic neuronal inclusion that is constantly found in the substantia nigra and locus ceruleus, and other specific brain regions in Parkinson's disease (PD). In the present study, the significance of nonparkinsonian cases in which the LBs were an incidental finding was inves-tigated.

In 1,452 autopsy series (age range, 1~89 years), 27 incidental cases of LBs and 21 patients with PD were found. The age-specific prevalence of inciden-tal LBs steadily increased from 0.7 % to 6.5 % between the sixth and ninth decades. The distribu-tion of LBs in incidental cases was similar to that in PD.

The number of neurons in the substantia nigra and locus ceruleus was determined in 8 incidental cases (age range, 60~81 years), 9 patients with PD (range, 56~81 years) and 9 control subjects (range, 60~81 years). In incidental cases, the average numbers of pigmented neurons in the substantia nigra and locus ceruleus was 83 % and 77 % of those in control subjects, respectively. In PD, the average numbers of pigmented neurons in the substantia nigra and locus ceruleus was 28 % and 19 % those of controls, respectively. However, the number of nonpigmented neurons in the substantia nigra was not reduced in incidental cases and PD.

From the above findings, it is suggested that there exists a close relationship between the occurrence of LBs and aging. However, in the brains of elderly patients, incidental LBs were considered to be patho-logical findings rather than simple aging phenome-non. Therefore, it has been suggested that inciden-tal cases may represent early and presymptomatic cases of PD.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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