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A Case of Motor Neuron Disease with IgM Gammopathy which showed Anti-cerebrum Antibody Toshio Matsuzaki 1 , Nobuyuki Kashio 1 , Hiroko Atsuji 1 , Mika Tokimura 1 , Masaru Kuriyama 1 , Mitsuhiro Osame 1 , Takashi Inuzuka 2 , Shuzo Sato 2 1The Third Department of Internal Medicine, Kagoshima University 2Department of Neurology, Brain Research Institute, Niigata University Keyword: motor neuron disease , IgM gammopathy , plasmapheresis , anti-cerebrum antibody pp.365-369
Published Date 1992/4/1
DOI https://doi.org/10.11477/mf.1406900325
  • Abstract
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A patient, 50-year-old female, developed progres-sive weakness of lower extremities, and gait distur-bance for 2 years.

Neurological examination revealed hyperreflexia with pathological reflex, fasciculation in the limbs and tongue, muscle weakness and atrophy in distal limbs, but no sensory disturbance. Needle EMG showed neurogenic findings compatible with motor neuron disease (MND).

Laboratory data showed polyclonal IgM hyperim-munoglobulinemia, positive several autoimmune antibodies including antisingle strand DNA anti-body (Ab), ENAab, SS-A ab and RA. There were no antibodies for gangliosides and Myelin-associat-ed glycoprotein (MAG), but positive antibody for 54KD protein of cerebral gray and white matter.

The clinical manifestations including gait distur-bance and muscle weakness, and serum IgM levelwere moderately improved by plasmapheresis which is considered important for consideration of causes of MND.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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