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Brain and Nerve No to Shinkei Volume 51, Issue 5 （May 1999）

Brain and Nerve 脳と神経 51巻5号（1999年5月発行）

Japanese English

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Neurological CPC・72

一過性に抗GM₁抗体陽性となりγ-グロブリン静注療法にて電気生理学的所見に改善が見られた下位運動ニューロン疾患の男性例 An Autopsy Case with Lower Motor Neuron Disease Showing a Transient Appearance of AntiGM₁ Antibody and an Improvement of Conduction Block after Gamma-Globulin Administration 菊池仁志 ^1,2 , 河野祐治 ¹ , 堂浦克美 ² , 河村忠雄 ¹ , 谷脇孝恭 ¹ , 山田猛 ¹ , 加藤元博 ³ , 岩城徹 ² , 吉良潤一 ¹ Hitoshi Kikuchi ^1,2 , Yuji Kawano ¹ , Katsumi Doh-ura ² , Tadao Kawamura ¹ , Takayuki Taniwaki ¹ , Takeshi Yamada ¹ , Motohiro Kato ³ , Toru Iwaki ² , Jun-ichi Kira ¹ ¹九州大学医学部神経内科 ²九州大学医学部脳研病理 ³九州大学医学部脳研生理 ¹Departments of Neurology, Faculty of Medicine, Kyushu University ²Departments of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University ³Departments of Neurophysiology, Neurological Institute, Faculty of Medicine, Kyushu University キーワード： motor neuron disease , multifocal motor neuropathy , anti-GM₁ antibody , conduction block , gamma-immunoglobulin therapy Keyword: motor neuron disease , multifocal motor neuropathy , anti-GM₁ antibody , conduction block , gamma-immunoglobulin therapy pp.455-464

発行日 1999年5月1日 Published Date 1999/5/1

DOI https://doi.org/10.11477/mf.1406901444

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症例呈示

　患者：63歳，男性（NP 98006）

　主訴：両上下肢筋力低下

We report a 63-year-old man who died of respira-tory failure. He was well until 1992 (57 years of his age), when he had an onset of progressive weakness of the bilateral upper limbs. He showed no improve-ment with TRH administration in other hospital. On January 12, 1994, he admitted to our department be-cause of the progressive muscle weakness. Neurologic examination revealed a muscular atrophy associated with severe weakness and hyporeflexia in both upper limbs, and fasciculation were seen in his tongue.