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TRANSPLANTATION OF THE SUPERIOR CERVICAL GANGLION INTO THE BRAIN:A NEW EXPERIMENTAL THERAPY FOR PARKINSON DISEASE Toru Itakura 1 , Ichiro Kamei 1 , Kunio Nakai 1 , Mitsukazu Nakai 1 , Yutaka Naka 1 , Kazuo Nakakita 1 , Harumichi Imai 1 , Norihiko Komai 1 1Department of Neurological Surgery Wakayama Medical College pp.285-290
Published Date 1988/3/1
DOI https://doi.org/10.11477/mf.1406206078
  • Abstract
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To supplement catecholamine deficit in the brain with Parkinson disease, we have aimed to trans-plant the superior cervical ganglion (SCG), which contains norepinephrine and dopamine, into the brain

1. Transplantation of SCG into rat cerebral cortex

SCG was transplanted into the same rat's pa-rietal cortex. Three weeks after the transplanta-tion, catecholamine histofluorescence revealed many transplanted catecholamine cells in the cortex. However, no fibers extended from the transplanted tissue to the cerebral cortex. Some catecholamine fibers extended to the cerebral cor-tex where 6-OHDA (a specific neurotoxin to thecatecholamine neuron) had been pretreated.

2. Transplantation of SCG into the caudate nucleus of MPTP-induced Parkinson monkey

For animal model of Parkinson disease, MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) was administered to 5 monkeys. Tow weeks after MPTP administration, dopamine terminals disap-peared in the caudate nucleus. After transplanta-tion of SCG in the same animal, many trans-planted SCG cells extended their axons to the caudate nucleus.

The present results showed that transplanted SCG cells were well survived in the brain. Under a special circumstance such as shortage of catecho-lamine in the brain, transplanted SCG cells ex-tended their axons into the brain. It is suggested that the transplantation of SCG can be a new therapy for Parkinson disease.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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