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Japanese

Dynamics of Extracellular Acetylcholine of the Gerbil Striatum During Cerebral Ischemia Monitored by Intracerebral Microdialysis Masami Ueno 1 , Toru Itakura 1 , Hideyoshi Yokote 1 , Harumichi Imai 1 , Takashi Okuno 1 , Norihiko Komai 1 1Department of Neurological Surgery, Wakayama Medical College Keyword: cerebral ischemia , striatum , acetylcholine , microdialysis pp.467-472
Published Date 1991/5/1
DOI https://doi.org/10.11477/mf.1406902070
  • Abstract
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Neurons in the hippocumpus and striatum are vulnerable to the ischemic insult. In the present study we focused on the vulnerability of acetyl-choline (ACh)-containing neurons in the striatum. To determine the change of ACh content in the striatum, we employed a simple sensive brain mi- crodialysis method with high performance liquid chromatographyelectrochemical detection. Mot.- phological change of cholinergic neurons was stud-ied by ACh-esterase staining during ischemic insult. After bilateral carotid artery occlusion, local cere-bral flow decreased less than 5ml/min/100g in the striatum. Ach content in dialysate for 20min afterthe occlusion was elevated to 135% of the control. ACh content decreased to 15% of the control 2hs after the ischemia. Density of Cholinergic fibers and cell bodies was reduced 10 min after the ischemia and further decreased 20min after the occlusion. Our study suggests that the trasient elevation of ACh content was probably due to diffusion of AChfrom destructed cholinergic terminals after the is-chemic insult. The increase of ACh immediately after arterial occlusion may affect severity of is-chemic damage in the brain by its excitatory effect.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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