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Brain and Nerve No to Shinkei Volume 27, Issue 5 （May 1975）

Brain and Nerve 脳と神経 27巻5号（1975年5月発行）

Japanese English

原著

小児重症筋無力症の甲状腺機能 THYROID FUNCTION IN MYASTHENIA GRAVIS IN CHILDHOOD 満留昭久 ^1,2 , 合屋長英 ^1,2 , 黒川徹 ^1,2 , 渡辺紀明 ^1,2 , 河野斉 ^1,2 Akihisa Mitsudome ^1,2 , Nagahide Goya ^1,2 , Toru Kurokawa ^1,2 , Noriaki Watanabe ^1,2 , Satoshi Kono ^1,2 ¹九州大学医学部小児科学教室 ²現在，福岡大学医学部小児科 ¹Department of Pediatrics, Faculty of Medicine, Kyushu University pp.529-533

発行日 1975年5月1日 Published Date 1975/5/1

DOI https://doi.org/10.11477/mf.1406203712

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Abstract 文献概要
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I．はじめに

　重症筋無力症と甲状腺機能亢進症の合併は今世紀初頭より注目されてきた。この2つの疾患の合併については，多方面からの研究がなされてきたが，近年甲状腺機能低下症との合併も注目されるようになつてきている。

　小児期の重症筋無力症と甲状腺機能亢進症の合併は，散発的な報告がみられるにすぎない^5,8,15）。

　私共は小児期の重症筋無力症の甲状腺機能について検討を加えたので報告する。

Thyroid function was studied in 54 cases withmyasthenia gravis in children and 43 persons oftheir parents and siblings.

Goiter was found in 5 (9%) of 54 cases withmyasthenia gravis.

Two cases had hyperthyroidism, and one of themturned to have hypothyroidism after the treatmentfor hyperthyroidism.

PBI level in serum was more than 8.0 μg/dl in8 cases (32%), and less than 3.5 μg/dl in one case.

Res-O-Mat T₃ was abnormally high with morethan 1.1 in 3 cases (14%), and abnormally lowwith less than 0.85 in one case. Res-O-Mat T₄was more than 14.0 μg/dl in three cases (14%), andless than 4.0 μg/dl in other 3 cases.

Positive thyroid test was noted in 10% of 28patients, and microsome test was positive in 15%of 26 patients.

Nine patients in our series were noticed to havegoiter or abnormal thyroid functions.

In the 6 family members of 51 families thyroiddisorders were noticed. And thyroid test was posi-tive in 20%, and positive microsome test wasnoticed in 40% of 25 mothers of the patients. Butin none of their fathers and siblings thyroid testor microsome test was positive.