脳腫瘍ミトコンドリアの脂酸構成

FATTY ACID COMPOSITION IN MITOCHONDRIA OF BRAIN TUMOR

I．はじめに

　脳腫瘍は正常脳と著しく異つた脂酸構成をもつている。この事実は両者間の脂酸代謝に相違があることを暗示している。

　脳の呼吸商は1であり，これは脳がほとんど糖のみを燃焼していることを意味している。これに対して腫瘍は代謝燃料として脂酸を酸化することが知られている。

1) The mitochondria were separated from normalbrain by Ozawa's method and brain tumor tissuesby Devlin's method. Then, the fatty acid compo-sitions of these mitochondria were analyzed.

2) Between white and gray matter, there wasno significant difference in the fatty acid compo-sitions of the mitochondria.

3) The fatty acid composition in mitochondriaof brain tumor was shown remarkable differencefrom that of normal brain. In both groups, C 16C 18 and C 18: 1 were found to be major fattyacids, however, we found that, in mitochondria ofbrain tumor, the percentages of these major fattyacids were low, and the percentages of C 18: 2 andshorter chain fatty acids than C 16 were high.

4) On the other hand, among the brain tumorsshowing different histological findings, there wasno significant difference in the fatty acid compo-sitions of their mitochondria.

5) The above mentioned facts suggest that thereaxists significant difference in energy metabolism,especially in the oxidative process of fatty acids,between normal brain and brain tumor.