脳腫瘍の脂質脂酸構成

LIPID AND FATTY ACID COMPOSITIONS OF BRAIN TUMOR

緒言

　我々は現在までの研究^24）25）において，比較的早期の脳腫瘍例の髄液脂酸を分析定量し，正常例と比較したところ，脂酸含有量が低下しているのを認めた。この結果より，脳腫瘍は正常脳と異なり，代謝燃料として脂酸をとりこみ，これを酸化するのではないかと推論した。またWeinhouse^19）20），Medes^4）等は各種腫瘍の脂酸代謝の研究を行ない，腫瘍がエネルギーの目的のために宿主から脂酸をとり入れ，これを利用することを認めている。ここで脳という特殊な環境に発生した腫瘍が，はたして一般組織に出来た腫瘍と同様な性格をもつかと云う疑問がわく。この問題に脂質脂酸代謝の方面よりアプローチする手段として脳腫瘍組織をとりあげ，Glioblasto—ma, Meningioma, Metastatic carcinomaの3例についてその脂質脂酸構成を比絞検討した。

1) Lipid and fatty acid compositions of three different brain tumor tissues (Glioblastoma, Menin-gioma and Metastatic Carcinoma.) were analyzed and compared with these of normal white andgray matter.

2) In lipid compositions of brain tumor tissues, the percentage of ethanolamine phospholipid and cerebroside were lower than these from normal brain. Cholesterol ester, which almost is not in-cluded in normal brain, was contained in brain tumor tissues.

3) Total phospholipid P and cholesterol, in quan-titative lipid fractions from brain tumor tissues, were lesser than these of normal brain.

4) The percentage of C18 and C18: 1, in fatty acid compositions of each lipid fractions from brain tumor tissues, were higher than these of normal brain, and C18: 2, which almost is not included in normal brain, was contained in brain tumor tissues.

5) In quantitative fatty acid compositions, fatty acid contents of brain tumor tissues were lesser than normal brain, and C18: 2 was contained in brain tumor tissues.

6) It is worthy of notice that odd number fatty acids were recognized in both brain tumor- and normal brain tissues.

7) In fatty acids and lipids compositions, various type of brain tumors were generally simulative, but were different from normal brain qualitatively and quantitatively. Therefore, we found that the metabolism of lipids and fatty acids show difference between brain tumor and normal brain.