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Japanese

RELATIONSHIP BETWEEN CHINOFORM DOSAGE AND EVOKED EMG FINDINGS IN SUBACUTE MYELO-OPTICO-NEUROPATY (SMON) Hajime Himei 1 , Yukinari Ozaki 1 , Hiroyuki Makihata 1 , Isao Miyoshi 2 , Takefumi Fuchimoto 2 , Kyoshi Hiraki 2 1Dept. of Medicine, Okayama Red Cross General Hospital 2Dept. of Medicine, Okayama Univ. Medical School pp.315-320
Published Date 1973/3/1
DOI https://doi.org/10.11477/mf.1406203289
  • Abstract
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We have studied evoked EMG on the tibial nerves in 31 cases of SMON with a proven history of chinoform administration, and the following results are obtained.

1) There was no close relationship between chino-form dosage per kg per day or total dosage or duration of its medication and maximum conduc-tion velocity (MCV) or M and H wave latencies, but MCV or the latencies of almost all the cases were delayed in the period when the drug was given, and recovered in the period when the drug was not given.

2) The form of M and H wave became polyphasic and diminished when a large quantity of chinoform was given, and clinical symptoms were severe. When a small dosage of the drug was given, the waves were almost normal, and clinical symptomswere slight.

3) Evoked EMG findings became almost stable in 6 months after the onset of SMON, and direct effects of chinoform on EMG appeared to be di-minished over 4 months after stopping the drug.

4) Evoked EMG findings and clinical symptoms of almost all the cases have improved gradually in long-term observation.


Copyright © 1973, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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