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Japanese

EXPERIMENTAL STUDIES ON PROTECTIVE EFFECT OF UBIQUINONE-9 AGAINST HISTOTOXIC ANOXIA INDUCED BY KCN Haruyuki Kanaya 1 , Takabumi Yamada 1 , Tadao Ohuchi 1 , Shigeo Kimoto 1 , Takehiko Matsuura 1 , Hiroshi Sakuma 1 1Department of Surgery and Neurosurgery, Iwata Medical University, School of Medicine pp.1625-1632
Published Date 1972/12/1
DOI https://doi.org/10.11477/mf.1406203239
  • Abstract
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We have investigated the effect of Ubiquinone-9 (CoQ9) on hystotoxic anoxia induced by KCN in rats, rabbits and dogs, and observed the following results.

1) The LD 50 of KCN in control rates was 3.55 mg/kg, while the LD 50 of KCN in rats given Ubiquinone-9 for seven days was 4.20 mg/kg. This suggests the effect of Ubiquinone-9 on the toxicity of KCN.

2) In dogs, KCN causes a typical histotoxic anoxia including the remarkable increase of cerebral oxygen tension, bradycardia, lowering of blood pressure and increase of cerebrospinal fluid pressure which tend to return normal after the administration of Ubiquinone-9.

3) The EEG changes of rabbits induced by KCN returns to normal after 60 minutes, but Ubiquinone-9 shortens the recovery time from 60 to 30 minutes.

4) Arhythmia induced by KCN in dogs was im-proved by Ubiquinone-9.


Copyright © 1972, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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