Acute Induced Anoxic Anoxia時における水分電解質代謝に関する研究

Water-Mineral Metabolism in Acute Induced Anoxic Anoxia.

緒言

　心肺疾患においてAnoxiaが病状を左右する主要な因子であることは衆知の事実であり，ことに水分電解質代謝の面からAnoxiaの影響を観察することは興味深い問題であるが，いまだその詳細は明らかにされていない。

　Iseri，McCaugheyらは71例の右室及び左室不全，あるいは肺水腫を伴う左室不全の症例について血清Na^＋，　K^＋濃度を測定し，その85％が正常平均値以上の値を示したと報告している^1）。一方Squires，Singer等は主として右室不全を示す44例の症例について血清Na^＋濃度の低下が見られたと述べているが^2），彼等の症例44例中36例が水銀剤治療を受けた例であることから，症例の差による成績の相違が考慮されなければならない。

The author's investigations on the water-mineral metabolism in acute induced anoxic anoxia (0₂15%) performed on 10 cases with minimum pulmonary tuberculosis reveal as follows:

After thirty minutes of induced anoxia, acid-base balance showed respiratory alkalosis; sodium and chloride shifted from intracellular to extracellular space, while no significant change was noticed in potassium. At the same time, water moved from intracellular to extracellular space, resulting in reduction of hematocrit and serum protein concentration. Urinary excretion of sodium, potassium and chloride as well as urinary volume were increased, and the tendency to alkalinizing of urine was observed.

Thirty minutes after recovery, acid-base balance still remained in respiratory alkalosis and urinary pH was also alkaline, but movements of water and minerals were reversed, i. e. from extracellular to intracellular space.