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Treatment of Disturbances of Extrapyramidal System with Methixene Hydrochloride Shoshiro KUROMARU 1 , Kazuhiko FUNASAKA 1 , Keiichi SCHUTTA 1 1Department of Neuropsychiatry, Kobe University, School of Medicine pp.1301-1309
Published Date 1969/11/1
DOI https://doi.org/10.11477/mf.1406202638
  • Abstract
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Fifty-four cases having disturbances of extra-pyramidal system (so-called parkinsonian syndrome or parkinsonism) were treated per os with methixene HCl (2.5 mg/tab.), derivative of thioxanthene.

Target symptoms were followings.

I. Various parkinsonism ensued on organic dis-eases of central nervous system ; chronic and residual state of cerebral arteriosclerosis, encephalomalacia, encephalitis, cerebral palsy, brain trauma, cervical trauma, epilepsia, lupus erythematodes, idiopathic, etc. totaling 15 cases.

II. Parkinsonism ensued on several kinds of py-chotropic drugs ;

(A) thiothixene (taking strong neurodyslepsia). 17 cases

(B) combinational administration with other drugs (ex. chlorpromazine, levomepromazine, perphenazine, thioridazaine, imipramine, etc.). 22 cases

With the daily dosage of 7.5 mg to 30 mg of methixene HCl the marked effect coming up to 60% improvement was attained in cases of the group I, and 58. 8% in the group (A) and 54. 5% in (B) both among the group II.

Investigating the result of the improved cases, the stronger activity to tremor was found in me-thixene HCl in comparison with its activities to rigidity or tonus of muscles and to autonomic im-balance.

On the other hand, only negligible side effects such as orthostatic hypotensive asthenia, hypotension, hypomyotonia of extremities, visual disorder, gastro-intestinal disorder, swallowing disorder, increase of sputa, urticaria were seen in a little over 20% cases at the above doses.

However these were well tolerated and so there was no need to discontinue the administration or to decrease the dosage.

Besides, also there is no disturbance in liver func-tion nor disorder of blood components in each case during 7-294 clays administration.

Thus, methixene HCl is considered as one of the most useful drugs of first choice against tremor or various disturbances from the extrapyramidal system.


Copyright © 1969, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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