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I.はじめに
近年,躁うつ病の長期lithium carbonate(以下,lithiumと略す)療法中に錐体外路症状を呈した症例が報告されるようになった1〜3,6〜11,13,14)。しかし管見の範囲内では本邦での報告例はみあたらない。
我々は,lithium治療中の入院・外来患者の錐体外路症状の発現頻度を調査し,21例中1例にこれを認めた。この1例について抗パーキンソン病薬投与,およびlithium減量による治療を試み,錐体外路症状に対する効果の観察を行ったので報告する。
Extrapyramidal side effects (EPS) without elevated serum lithium levels have been observed recently in patients with affective disorders under long-term lithium therapy. The authors examined, from a neurological point of view, 21 patients who had received lithium therapy for at least 2 months without concomitant neuroleptics. Of the 21 patients, EPS was eliminated in only one case (4.8%). The case: A female inpatient of 71 suffering from bipolar disorder had received neuroleptics and tricyclics successively for three years. Both drugs were discontinued on admission and lithium treatment started with 600mg/day.
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