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Japanese

ANALYSIS OF EEG CHANGES DURING ORAL ADMINISTRATION OF AMMONIUM CITRATE IN 2 CASES WITH HEPATO-CEREBRAL SYNDROME Mitsuo YOSHIDA 1 , Yukitaka MIYACHI 1 , Kazuteru OGIWARA 1 , Toshiji MOZAI 1 , Kiku NAKAO 1 1The Third Department of Internal Medicine, University of Tokyo pp.1229-1236
Published Date 1968/12/1
DOI https://doi.org/10.11477/mf.1406202474
  • Abstract
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The report dealed with the 2 cases which showed unconscious attacks or extrapyramidal disorders ; with underlying disorders of the Budd Chiari Syn-drome in the one case and the hepatic cirrhosis in the other. Either of them was clinically charac-terized by hyperammonemia and by abundant for-mation of the collaterals between the portal vein and the vena cava inferior. Thus both of them, together with the neuropsychiatric symptoms, could be classified as the "specific form of hepato-cerebral degeneration" proposed by Inose.

Under the general assumption that the increased ammonia level in blood plays an important role for inducing the neuropsychiatric symptoms, especially in the cases with the abundant collateral formation, ammonium citrate was administered to them ; doses of which being 21 gr. and 14 gr., respectively. Sim-ultaneous recordings of the blood ammonia level as well as EEG changes were analysed quantitavely through EEG analyser equipment, revealed that there was a concomitant parallelism between the in-creased level of blood ammonia and increased amount of the slow waves in EEG. Comment of the results were made refering the related literatures.


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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