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ON CLINICAL USE OF DETERMINATION OF REGIONAL CEREBRAL BLOOD FLOW BY Kr85 DESATURATION METHOD Kazuhiko OKAMURA 1 12nd Dept. of Surgery, Nagoya Univ. School of Med. pp.1041-1049
Published Date 1965/10/1
DOI https://doi.org/10.11477/mf.1406201932
  • Abstract
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The quantitative measurements of the regional cerebral blood flow through the intact skull applying the method devised by Lassen et al. were performed on thirty-eight patients.

For the purpose of recording from a more circum-scribed area, we used a cylindrical lead collimator of 3.5cm. in diamter and 5cm. in length, and thus obtained counting of much narrower area which was confined within the limits of a lobe of the hemisphere.

The normal value of the regional cerebral blood flow (CBFr) in the frontal and the temporal region ranged from 52 to 65ml. per 100g. per minute, and from 54.0 to 71.2ml. respectively.

The mean value of CBFr in 6 patients with posttraumatic disorders was 85.2ml. in the frontal, and 37.0ml. in the temporal.

The mean value of CBFr in 6 patients with brain tumors was 33.8ml. in the temporal. These results showed that the higher the intranial pressure rose, the more severely decreased the CBFr. In a patient with approximately 200g. of angioblastic meningioma in the right parietal region, CBFr was increased over the normal value in the right temporal region in accordance with the tumor. On the contrary, it decreased severely in the opposite side probably due to the increased intracranial pressure. After removal of the tumor, CBFr restored to the normal range, namely by decreasing in the affected side and increasing in the opposite hemisphere.

In 3 patients with occlusion of the middle cerebral artery, the reduction of CBFr was evidently observed in accordance with the lesion.

Such a local change of the cerebral blood flow in these occlusive diseases would not be detected by such a method for measuring the total blood flow as N2O method by Kety and Schmidt.

The mean value of 5 patients with cerebral arterio-sclerosis was 35.4 in the frontal and 37.1ml. in the temporal region respectively.

In 4 patients with internal carotid occlusive disease, the mean value was 29.0 on affected side, and 40.2 ml. on the opposite side.

In conclusion, this method has many advantages over the other methods for measuring the cerebral blood flow. First, it can be detected a local change of the cerebral blood flow which might be missed in measurement of total cerebral blood flow as N2O method. In the second place, it can be performed very rapidly without much difficulties, and repeated measurements are possible.


Copyright © 1965, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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