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Magnesium Deficency in Patients with Vasospastic Angina Shozo Sueda 1 , Hideyuki Saeki 1 , Takashi Otani 1 , Naoto Ochi 2 , Hiroshi Fukuda 2 , Hitoshi Kukita 2 , Hiroyuki Kawada 3 , Shouzou Matsuda 3 , Tadao Uraoka 3 1Department of Cardiology, Saiseikai Saijo Hospital 2Department of Cardiology, Uwajima Social Insurance Hospital 3Department of Cardiology, Kita Medical Associa-tion Hospital Keyword: 冠攣縮 , マグネシウム欠乏 , 異型狭心症 , coronary vasospasm , magnesium deficiency , variant angina pp.511-515
Published Date 1999/5/15
DOI https://doi.org/10.11477/mf.1404901900
  • Abstract
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 The purpose of this study is to determine whether magnesium deficiency was present or not in patients with vasospastic angina. From 1993 June to 1995 December, 84 consecutive angiographically confirmed patients with vasospastic angina, consisting of 72 men and of 12 women with a mean age of 63.3±6.9 years old were studied. These consisted of 31 patients with variant angina pectoris and 53 patients in whom there was no demonstration of ST segment elevation. 28 of these patients had fixed stenosis (≥75%). As a control 19 patients in whom no spasm had been provoked by pharmacologic agents were also studied. Serum concentration levels of magnesium, calcium and potassium and total amount of urinary excretion of magnesium for 24 hours were measured on both the first and second day of the magnesium retention test. There was no difference in serum electrolyte levels on either the just or second day between patients with vasospastic angina and controls. However, the 24-hour magnesium retention rate was significantly higher (p<0.01) in patients with vasospastic angina (58.7±26.8%) than in the controls (44.7±11.7%). In patients with vasospastic angina, the value of the 24-hour magnesium retention rate didn't differ between patients with variant angina and nonvariant angina or between patients with fixed stenosis and non-fixed stenosis. However, in patients with variant angina, the value of the 24-hour magnesium retention rate was higher in patients without fixed stenosis than those with fixed stenosis but was not different between 2 groups. Seven patients who were treated with calcium-channel blockers and isosorbide dinitrates for at least 1 month showed a greater improvement of magnesium deficiency as chest symptoms worsened.

 In conclusion, magnesium deficiency was present in patients with not only variant angina but also nonvariant angina.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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