難治性冠攣縮性狭心症に対し，塩酸ジルチアゼムに塩酸ベニジピンを追加併用することによりコントロールを得た2例

Beneficial Effect of Additional Administration of Benidipine Hydrochloride on the Control of Anginal Attacks in Refractory Coronary Vasospasm:A report of two cases

　冠攣縮性狭心症の発作予防に対して，カルシウム拮抗薬が極めて有用である．今回われわれは，冠攣縮性狭心症患者に数種のカルシウム拮抗薬による発作予防を試みたが，単独および併用療法に抵抗性を示し，塩酸ジルチアゼムと塩酸ベニジピンの併用で狭心症発作がコントロールできた2例を経験した．治療に抵抗性を示す難治性冠攣縮性狭心症に対し，塩酸ベニジピンとの併用が有効な症例があると考えられ報告した．

It is widely recognized that calcium antagonists areeffective in the prevention of anginal attacks in patientswith coronary vasospasm. Here, we report two cases ofrefractory vasospastic angina which could be controlledby the combination therapy of benidipine hydrochlorideand diltiazem hydrochloride, while other calcium antag-onists were ineffective in preventing anginal attacks.This report suggests that benidipine hydrochloride maybe regarded as one of the drugs which should be tried foruncontrollable vasospastic angina.