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A Case of Familial Hypercholesterolemia (FH) with Angina Pectoris Related to Coronary Spasm and Microcirculatory Disturbance Akira Ido 1 , Yoshinao Ishii 1 , Takahiro Shiokoshi 1 , Kazumi Akasaka 1 , Tomoya Hirayama 1 , Yasuhiro Nakamura 1 , Fiji Kawashima 1 , Yuji Ogawa 1 , Naoyuki Hasebe 1 , Hirohisa Yamashita 1 , Kenjiro Kikuchi 1 1First Department of Internal Medicine, Asahikawa Medical College Keyword: 家族性高コレステロール血症 , 冠攣縮 , 冠微小循環障害 , familial hypercholesterolemia , coronary vasospasm , coronary microcirculatory disturbance pp.83-86
Published Date 1995/1/15
DOI https://doi.org/10.11477/mf.1404900993
  • Abstract
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A 47-year old woman who complained of chest pain, was admitted to our hospital. We diagnosed her illness as FH from hypercholesterolemia. tendon xanthoma and familial history. A treadmill exercise test showed ST-segment depression at the broad leads on ECG with chest pain. Tl-201 myocardial scintigraphy revealed exercise-induced transient myocardial perfusion defect indicating anterior and lateral wall ischemia. Coronary angiogram (CAG) did not show any significant stenosis except for 90% stenosis of #4AV. During atrial rapid pacing test. ECG showed an ischemic ST-segment depression accompanied by chest pain, without coro-nary spasms on CAG. In contrast, epicardial coronary spasm with chest pain and ischemic ST-segment depres-sion was provoked in all three coronary arteries by intracoronary administration of acetylcholine.

To the best of our knowledge, this is the first report of FH with angina pectoris possibly resulting from epicardial coronary spasms and impaired coronary microcirculation.


Copyright © 1995, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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