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Mechanism of Myocardial Protection with Potassium Arrest in Isolated Ischemic Rat Hearts Hideaki Yoshino 1,2 Keyword: 高カリウム心停止(potassium arrest) , 虚血再灌流障害(ischemia-reperfusion injury) , Na/K ATPase(sodium-potassium ATPase) pp.1151-1157
Published Date 1991/11/15
DOI https://doi.org/10.11477/mf.1404900382
  • Abstract
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Isolated working rat hearts were exposed to 25 min ischemia, and functional recovery was assessed by aortic flow (AoF) and rate-pressure product (RPP) to evaluate the beneficial effects of potassium (20 mM) induced arrest (K-arrest) prior to ischemia. K-arrest improved the recovery of function after 30min of reper-fusion compared with the control group (%AoF: 68±6 vs 0%, %RPP: 90±3% vs 60±3%, p<0.01). The accu-mulation of Ca++ at the end of reperfusion was less in hearts with K-arrest (2.2±0.1 vs 4.5±0.3μmol/g dry, p<0.01). There was no difference between the two groups in high energy phosphate content at the end of ischemia.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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